GPS is a bisulfite-based, location-specific whole-genome methylation sequencing technology that achieves up to 96% cytosine coverage and improved accuracy over WGBS.
Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks. Li J, Li Y, Li W, et al.. Genome Research. 2019;29(2):270–280.
Rapid genome-wide profiling of DNA methylation and genetic variation using guide positioning sequencing (GPS). Zhang B, Li W, Li J, et al.. Frontiers in Cell and Developmental Biology. 2024;12:1457387.